Studies on the mechanism of action of ACNU, 1-(4-amino-2-methylpyrimidine-5-yl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride: Effects on cultured HeLa S3 cells.
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منابع مشابه
Effect of 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride on experimental brain tumors.
permits easy passage across the blood-brain barrier. Others have argued that since brain tumors do not possess a blood brain barrier, the lipid solubility of the nitrosoureas can play no robein their therapeutic effectiveness. We have tested ACNU, a water-soluble nitrosourea, for its chemotherapeutic effect in several animal brain tumor models and have compared ACNU to other more lipid-soluble ...
متن کاملEffect of 1-(4-Amino-2-methyl-5-pyrimidinyl)methyl-342-chloroethyl}. 3-nitrosourea Hydrochloride on Experimental Brain Tumors'
permits easy passage across the blood-brain barrier. Others have argued that since brain tumors do not possess a blood brain barrier, the lipid solubility of the nitrosoureas can play no robein their therapeutic effectiveness. We have tested ACNU, a water-soluble nitrosourea, for its chemotherapeutic effect in several animal brain tumor models and have compared ACNU to other more lipid-soluble ...
متن کاملHypothetical mechanism of therapeutic synergism induced by the combination of 6-thioguanine and 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride.
Comparative studies were carried out using various antimetabolites in order to determine whether the synergistic cellkilling effect on L1210 murine leukemia cells induced by a treatment combining 6-thioguanine (6-TG) and 3-[(4-amino2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride (ACNU) resulted from "complementary inhibi tion." The combinations of ACNU plus 5-fluoro...
متن کاملCombination chemotherapy with 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride and bleomycin in meningeal carcinomatosis in rats.
Combination chemotherapy with 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU) and bleomycin (BLM) was evaluated using an experimental model of meningeal carcinomatosis induced in Sprague-Dawley rats by intracisternal inoculation of 1 X 10(4) Walker 256 tumor cells. Tumor-bearing animals were treated by i.v. administration of cyclophosphamide, BLM, A...
متن کاملEffect of 3-[4-amino-2-methyl-5-pyrimidinyl)ethyl[-1(2-chloroethyl)-1-nitrosourea hydrochloride on lymphoid leukemia L-1210.
A water-soluble nitrosourea, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride (ACNU), was tested for antitumor activity against lymphoid leukemia L-1210 in BDF1 mice. The results obtained were as follows: (1) ip--ip system: By daily administrations optimal dose for 12 days, MED (ILS40), and therapeutic ratio were found to be 18 mg/kg, 1.3 mg/kg, and 14, r...
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ژورنال
عنوان ژورنال: The Tohoku Journal of Experimental Medicine
سال: 1980
ISSN: 0040-8727,1349-3329
DOI: 10.1620/tjem.132.431